منابع مشابه
The new oral anticoagulants.
Although their first application in clinical practice occurred in the 1940s, vitamin K antagonists remain the only form of oral anticoagulant medication approved for long-term use. Although the available vitamin K antagonists are highly effective for the prevention and/or treatment of most thrombotic disease, the significant interpatient and intrapatient variability in dose-response, the narrow...
متن کاملOral anticoagulants and cyclosporin A
Haematologica vol. 85(8):August 2000 min-K dependent proteins, revealed that the affected amino acid was highly conserved, indicating an important structural or functional role. The search for other established thrombophilic genetic risk factors such as protein S and antithrombin deficiency, factor V Leiden, methylene tetrahydrofolate reductase C677T variant, and prothrombin G20210A variant rev...
متن کاملSpecial feature Oral anticoagulants
Oral anticoagulants are used to manage a variety of common age-related conditions (e.g., atrial fibrillation), and the frequency of their use will likely rise significantly in the United States as the population ages. The number of elderly Americans 65 years of age or older is expected to increase markedly over the next two decades, from 39.6 million in 2009 to 72.1 million by 2030. Nearly one ...
متن کاملReversal of direct oral anticoagulants
Reversal agents for direct oral anticoagulants (DOACs), including factor X inhibitors and direct thrombin inhibitors, are a major concern in clinical practice. After DOACs were introduced and became widely used as an alternative for vitamin K antagonists in the management of venous thromboembolism and nonvalvular atrial fibrillation, the need for effective reversal agents has increased, particu...
متن کاملNew oral anticoagulants in development.
Although currently available anticoagulants are effective for the prevention and treatment of thromboembolic disorders, they have several drawbacks. Low-molecular-weight heparins and fondaparinux produce a predictable level of anticoagulation that obviates the need for coagulation monitoring, but they must be given parenterally, which renders them inconvenient for long-term use. Vitamin K antag...
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ژورنال
عنوان ژورنال: The Lancet
سال: 1996
ISSN: 0140-6736
DOI: 10.1016/s0140-6736(05)65857-6